[HTML][HTML] Role of the mitochondrial protein import machinery and protein processing in heart disease

F Zhao, MH Zou - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Mitochondria are essential organelles for cellular energy production, metabolic
homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of …

HIF‐1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia

P Alanova, L Alan, B Opletalova… - Acta …, 2024 - Wiley Online Library
Aim The transcriptional factor HIF‐1α is recognized for its contribution to cardioprotection
against acute ischemia/reperfusion injury. Adaptation to chronic hypoxia (CH) is known to …

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

D Benak, K Holzerova, J Hrdlicka, F Kolar, M Olsen… - RNA biology, 2024 - Taylor & Francis
Cardiac tolerance to ischaemia can be increased by dietary interventions such as fasting,
which is associated with significant changes in myocardial gene expression. Among the …

A systematic review on the selection of reference genes for gene expression studies in rodents: are the classics the best choice?

TT Bunde, ACK Pedra, NR de Oliveira… - Molecular Biology …, 2024 - Springer
Rodents are commonly used as animal models in studies investigating various experimental
conditions, often requiring gene expression analysis. Quantitative real-time reverse …

[HTML][HTML] A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma

J De Backer, D Maric, M Bosman, S Dewilde… - Scientific Reports, 2021 - nature.com
Cytoglobin (CYGB) is a ubiquitously expressed protein with a protective role against
oxidative stress, fibrosis and tumor growth, shown to be transcriptionally regulated under …

[HTML][HTML] Selection of suitable internal controls for gene expression normalization in rats with spinal cord injury

W Liu, J Yu, YF Wang, QQ Shan… - Neural Regeneration …, 2022 - journals.lww.com
There is a lack of systematic research on the expression of internal control genes used for
gene expression normalization in real-time reverse transcription polymerase chain reaction …

[HTML][HTML] Unveiling the proteome of the fasting heart: Insights into HIF-1 pathway regulation

D Benak, K Holzerova, F Kolar, M Chalupova… - Frontiers in …, 2024 - frontiersin.org
Fasting is a common dietary intervention known for its protective effects against metabolic
and cardiovascular diseases. While its effects are mostly systemic, understanding tissue …

[HTML][HTML] Reference genes for proximal femoral epiphysiolysis expression studies in broilers cartilage

LM Hul, AMG Ibelli, JO Peixoto, MR Souza, IR Savoldi… - PLoS …, 2020 - journals.plos.org
The use of reference genes is required for relative quantification in gene expression
analysis and the stability of these genes can be variable depending on the experimental …

Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased …

M Höfner, K Eubler, C Herrmann, U Berg… - Molecular Human …, 2024 - academic.oup.com
Oxygen (O2) concentrations have recently been discussed as important regulators of
ovarian cells. Human IVF-derived granulosa cells (human GCs) can be maintained in vitro …

Identification and validation of reference genes selection in ovarian cancer exposed to hypoxia

W Yan, M Xie, R Li, H Hu, B Tang… - OncoTargets and …, 2020 - Taylor & Francis
Introduction Hypoxia-mediated tumor metastasis, progression and drug resistance are major
clinical challenges in ovarian cancer. Meanwhile, the genetic basis of these traits is still not …