DNA end resection: mechanism and control
P Cejka, LS Symington - Annual review of genetics, 2021 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …
Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …
[HTML][HTML] Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection
I Ceppi, MR Dello Stritto, M Mütze, S Braunshier… - Nature, 2024 - nature.com
DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA
end resection, a process involving the controlled degradation of the 5′-terminated strands …
end resection, a process involving the controlled degradation of the 5′-terminated strands …
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases
L Zheng, Y Meng, JL Campbell… - Nucleic acids research, 2020 - academic.oup.com
DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …
Single-strand break end resection in genome integrity: mechanism and regulation by APE2
DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
Enhancement of BLM-DNA2-mediated long-range DNA end resection by CtIP
JM Daley, J Jimenez-Sainz, W Wang, AS Miller, X Xue… - Cell reports, 2017 - cell.com
DNA double-strand break repair by homologous recombination entails the resection of DNA
ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and …
ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and …
CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection
To repair a DNA double-strand break by homologous recombination, 5′-terminated DNA
strands must first be resected to reveal 3′-overhangs. This process is initiated by a short …
strands must first be resected to reveal 3′-overhangs. This process is initiated by a short …
Rad52 restrains resection at DNA double-strand break ends in yeast
Rad52 is a key factor for homologous recombination (HR) in yeast. Rad52 helps assemble
Rad51-ssDNA nucleoprotein filaments that catalyze DNA strand exchange, and it mediates …
Rad51-ssDNA nucleoprotein filaments that catalyze DNA strand exchange, and it mediates …
PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-
range resection to stimulate MRE11–RAD50–NBS1 (MRN) to endonucleolytically cleave …
range resection to stimulate MRE11–RAD50–NBS1 (MRN) to endonucleolytically cleave …
Mechanism and significance of chromosome damage repair by homologous recombination
Homologous recombination (HR) is a major, conserved pathway of chromosome damage
repair. It not only fulfills key functions in the removal of deleterious lesions such as DNA …
repair. It not only fulfills key functions in the removal of deleterious lesions such as DNA …