Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …

Spinal cord injury (SCI) triggers complex inflammatory and pathological processes that
ultimately lead to scar formation, thus resulting in the severe and irreversible loss of function …

Growing evidence implicates the importance of glia, particularly astrocytes, in neurological
and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of motor neurons in the CNS. Astrocytes play a critical role in disease …

Human astrocytes network with neurons in dynamic ways that are still poorly defined. Our
ability to model this relationship is hampered by the lack of relevant and convenient tools to …

Our understanding of astrocytes and their role in neurological diseases has increased
considerably over the past two decades as the diverse roles of these cells have become …

ABSTRACT ALS (amyotrophic lateral sclerosis), the most common motor neuron disease,
causes muscle denervation and rapidly fatal paralysis. While motor neurons are the most …

In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC
transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their
differentiation into neural lineages is a revolutionary experimental system for studying …

Transplantation-based replacement of lost and/or dysfunctional astrocytes is a promising
therapy for spinal cord injury (SCI) that has not been extensively explored, despite the …