Macrophages are cells of the innate immune system that regulate the maintenance of tissue
homeostasis, host defense during pathogen infection, and tissue repair in response to tissue …

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …

Oxidative stress contributes to the pathogenesis of acute lung injury. Protein S-
glutathionylation plays an important role in cellular antioxidant defense. Here we report that …

As humans evolved, perhaps the two strongest selection determinants of survival were a
robust immune response able to clear bacterial, viral, and parasitic infection and an ability to …

The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage
and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in …

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the
last two decades there has been a dramatic growth in our understanding of LD biology and …

The benefits of endurance exercise on general health make it desirable to identify orally
active agents that would mimic or potentiate the effects of exercise to treat metabolic …

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree …

Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin
resistance and type 2 diabetes. While inflammatory activation of resident hepatic …

The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose
differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3–12, and …