Exploring plant metabolic genomics: chemical diversity, metabolic complexity in the biosynthesis and transport of specialized metabolites with the tea plant as a model

J Zhao, P Li, T Xia, X Wan - Critical Reviews in Biotechnology, 2020 - Taylor & Francis
The diversity and complexity of secondary metabolites in tea plants contribute substantially
to the popularity of tea, by determining tea flavors and their numerous health benefits. The …

More than a Catharanthus plant: a multicellular and pluri-organelle alkaloid-producing factory

N Kulagina, LV Méteignier, N Papon… - Current Opinion in Plant …, 2022 - Elsevier
Plants represent a huge reservoir of natural products. A broad series of these compounds
now find application for human health. In this respect, the monoterpene indole alkaloids …

Single-cell RNA sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism

S Sun, X Shen, Y Li, Y Li, S Wang, R Li, H Zhang… - Nature plants, 2023 - nature.com
Monoterpenoid indole alkaloids (MIAs) are among the most diverse specialized metabolites
in plants and are of great pharmaceutical importance. We leveraged single-cell …

Export of defensive glucosinolates is key for their accumulation in seeds

D Xu, NCH Sanden, LL Hansen, ZM Belew… - Nature, 2023 - nature.com
Plant membrane transporters controlling metabolite distribution contribute key agronomic
traits,,,,–. To eliminate anti-nutritional factors in edible parts of crops, the mutation of …

Membrane transporters: the key drivers of transport of secondary metabolites in plants

U Gani, RA Vishwakarma, P Misra - Plant Cell Reports, 2021 - Springer
Key message This review summarizes the recent updates in the area of transporters of plant
secondary metabolites, including their applied aspects in metabolic engineering of …

Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

The complexity of intercellular localisation of alkaloids revealed by single‐cell metabolomics

K Yamamoto, K Takahashi, L Caputi, H Mizuno… - New …, 2019 - Wiley Online Library
Catharanthus roseus is a medicinal plant well known for producing bioactive compounds
such as vinblastine and vincristine, which are classified as terpenoid indole alkaloids (TIA s) …

[HTML][HTML] The emerging role of the nitrate and peptide transporter family: NPF in plant specialized metabolism

C Kanstrup, HH Nour-Eldin - Current Opinion in Plant Biology, 2022 - Elsevier
The nitrate and peptide transporter family (NPF) is one of the largest transporter families in
the plant kingdom. The name of the family reflects the substrates (nitrate and peptides) …

Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants

AH Vu, M Kang, J Wurlitzer, S Heinicke… - Journal of the …, 2024 - ACS Publications
Plants produce an extraordinary array of natural products (specialized metabolites). Notably,
these structurally complex molecules are not evenly distributed throughout plant tissues but …

Plant secondary metabolite transporters: Diversity, functionality, and their modulation

P Nogia, PK Pati - Frontiers in Plant Science, 2021 - frontiersin.org
Secondary metabolites (SMs) play crucial roles in the vital functioning of plants such as
growth, development, defense, and survival via their transportation and accumulation at the …