Evidence-based clinical practice guidelines for Liver Cirrhosis 2020

H Yoshiji, S Nagoshi, T Akahane, Y Asaoka… - Journal of …, 2021 - Springer
The first edition of the clinical practice guidelines for liver cirrhosis was published in 2010,
and the second edition was published in 2015 by the Japanese Society of Gastroenterology …

Expert panel review to compare FDA and EMA guidance on drug development and endpoints in nonalcoholic steatohepatitis

R Loomba, V Ratziu, SA Harrison… - …, 2022 - gastrojournal.org
Nonalcoholic steatohepatitis (NASH) has become a focus for drug development owing to its
increasing prevalence and health care burden. The global prevalence of NASH is estimated …

Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis

Y Tahata, H Hikita, S Mochida, N Enomoto… - Journal of …, 2022 - Springer
Background Direct-acting antiviral (DAA) therapy enables a high rate of sustained virologic
response (SVR) in patients with hepatitis C virus associated cirrhosis. However, the impact …

The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan

H Enomoto, Y Ueno, Y Hiasa, H Nishikawa… - Journal of …, 2021 - Springer
Background We recently reported the real-world changes in the etiologies of liver cirrhosis
(LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular …

Viral hepatitis C therapy: pharmacokinetic and pharmacodynamic considerations: a 2019 update

EJ Smolders, AME Jansen, PGJ Ter Horst… - Clinical …, 2019 - Springer
It has been estimated by the World Health Organization (WHO) that over 71 million people
were infected with the hepatitis C virus (HCV) in 2015. Since then, a number of highly …

Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study

Y Tahata, H Hikita, S Mochida, N Kawada… - Journal of …, 2021 - Springer
Background Real-world data on the efficacy and safety of sofosbuvir plus velpatasvir
(SOF/VEL) treatment for patients with hepatitis C virus (HCV)-related decompensated …

Direct-acting antivirals improve survival and recurrence rates after treatment of hepatocellular carcinoma within the Milan criteria

H Ochi, A Hiraoka, M Hirooka, Y Koizumi… - Journal of …, 2021 - Springer
Background The effects of direct-acting antivirals (DAAs) on survival and recurrence rates
after curative hepatocellular carcinoma (HCC) treatment in patients with hepatitis C virus …

Japan Society of Hepatology guidelines for the management of hepatitis C virus infection: 2019 update

Drafting Committee for Hepatitis … - Hepatology …, 2020 - Wiley Online Library
The Drafting Committee for Hepatitis Management Guidelines established by the Japan
Society of Hepatology (JSH) drafted the first version of the clinical practice guidelines for the …

A machine learning-based treatment prediction model using whole genome variants of hepatitis C virus

H Haga, H Sato, A Koseki, T Saito, K Okumoto… - PloS one, 2020 - journals.plos.org
In recent years, the development of diagnostics using artificial intelligence (AI) has been
remarkable. AI algorithms can go beyond human reasoning and build diagnostic models …

Real‐world clinical outcomes of sofosbuvir and velpatasvir treatment in HCV genotype 1‐and 2‐infected patients with decompensated cirrhosis: a nationwide …

T Tada, M Kurosaki, S Nakamura… - Journal of Medical …, 2021 - Wiley Online Library
The real‐world virological efficacy and safety of interferon‐free direct‐acting antiviral (DAA)
therapy with sofosbuvir (SOF) and velpatasvir (VEL) were assessed in hepatitis C virus …