Collagen-and hyaluronic acid-based hydrogels and their biomedical applications

Q Xu, JE Torres, M Hakim, PM Babiak, P Pal… - Materials Science and …, 2021 - Elsevier
Hydrogels have been widely investigated in biomedical fields due to their similar physical
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …

Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

[HTML][HTML] A tough act to follow: Collagen hydrogel modifications to improve mechanical and growth factor loading capabilities

SO Sarrigiannidis, JM Rey, O Dobre… - Materials Today Bio, 2021 - Elsevier
Collagen hydrogels are among​ the most well-studied platforms for drug delivery and in situ
tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility …

A review on the design and hydration properties of natural polymer-based hydrogels

AH Karoyo, LD Wilson - Materials, 2021 - mdpi.com
Hydrogels are hydrophilic 3D networks that are able to ingest large amounts of water or
biological fluids, and are potential candidates for biosensors, drug delivery vectors, energy …

Advances in regenerative medicine and tissue engineering: innovation and transformation of medicine

K Dzobo, NE Thomford, DA Senthebane… - Stem cells …, 2018 - Wiley Online Library
Humans and animals lose tissues and organs due to congenital defects, trauma, and
diseases. The human body has a low regenerative potential as opposed to the urodele …

Hydrogels for tissue engineering: addressing key design needs toward clinical translation

F Xu, C Dawson, M Lamb, E Mueller… - … in bioengineering and …, 2022 - frontiersin.org
While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted
significant interest in the development of functional hydrogel-based tissue engineering …

[HTML][HTML] ECM and ECM-like materials—Biomaterials for applications in regenerative medicine and cancer therapy

S Hinderer, SL Layland, K Schenke-Layland - Advanced drug delivery …, 2016 - Elsevier
Regenerative strategies such as stem cell-based therapies and tissue engineering
applications are being developed with the aim to replace, remodel, regenerate or support …

Mimicking the hierarchical organization of natural collagen: toward the development of ideal scaffolding material for tissue regeneration

L Salvatore, N Gallo, ML Natali, A Terzi… - … in Bioengineering and …, 2021 - frontiersin.org
Biological materials found in living organisms, many of which are proteins, feature a
complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in …

Decoupling the effects of stiffness and fiber density on cellular behaviors via an interpenetrating network of gelatin-methacrylate and collagen

AJ Berger, KM Linsmeier, PK Kreeger, KS Masters - Biomaterials, 2017 - Elsevier
The extracellular microenvironment provides critical cues that guide tissue development,
homeostasis, and pathology. Deciphering the individual roles of these cues in tissue …

[HTML][HTML] Synthesis of bioinspired collagen/alginate/fibrin based hydrogels for soft tissue engineering

G Montalbano, S Toumpaniari, A Popov, P Duan… - Materials science and …, 2018 - Elsevier
Hydrogels based on natural polymers offer a range of properties to mimic the native
extracellular matrix, and provide microenvironments to preserve cellular function and …