Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …

Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …

The development of atomic force microscopy (AFM) has opened up a wide range of novel
opportunities in nanoscience and new modalities of observation in complex biological …

Amyloid formation is a hallmark of many medical diseases including diabetes type 2,
Alzheimer's and Parkinson diseases. Under these pathological conditions, misfolded …

Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins
and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein …

Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling
and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies …

Abrupt aggregation of misfolded proteins is a hallmark of a large number of severe
pathologies, including diabetes types 1 and 2, Alzheimer, and Parkinson diseases. A …

Phosphatidic acid (PA) is a unique plasma membrane lipid that contains fatty acids (FAs)
with different lengths and degrees of unsaturation. Under physiological conditions, PA acts …

The progressive accumulation of transthyretin (TTR), a small protein that transports
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …

Proteinaceous deposits of α-synuclein amyloid fibrils are a hallmark of human disorders
including Parkinson's disease. The onset of this disease is also associated with five familial …