Pharmacotherapy of obesity: available medications and drugs under investigation

E Pilitsi, OM Farr, SA Polyzos, N Perakakis… - Metabolism, 2019 - Elsevier
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity

R Gutierrez, E Fonseca, SA Simon - Cellular and Molecular Life Sciences, 2020 - Springer
Throughout the animal kingdom sucrose is one of the most palatable and preferred tastants.
From an evolutionary perspective, this is not surprising as it is a primary source of energy …

[HTML][HTML] Gene variants in eating disorders. Focus on anorexia nervosa, bulimia nervosa, and binge-eating disorder

K Donato, MR Ceccarini, K Dhuli, G Bonetti… - Journal of preventive …, 2022 - ncbi.nlm.nih.gov
Eating disorders such as anorexia nervosa, bulimia nervosa and binge-eating disorder,
have a deep social impact, concluding with death in cases of severe disease. Eating …

Role of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake

A Joshi, M Schott, SE La Fleur, M Barrot - Neuroscience & Biobehavioral …, 2022 - Elsevier
Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in
all animals. However, when fat and sugar consumption goes beyond the daily needs, it can …

In vivo electrophysiological recordings of the effects of antidepressant drugs

PJ Fitzgerald, BO Watson - Experimental Brain Research, 2019 - Springer
Antidepressant drugs are a standard biological treatment for various neuropsychiatric
disorders, yet relatively little is known about their electrophysiologic and synaptic effects on …

Gender‐related issues in the pharmacology of new anti‐obesity drugs

M Cataldi, G Muscogiuri, S Savastano… - Obesity …, 2019 - Wiley Online Library
Four new medicines—liraglutide, lorcaserin, bupropion/naltrexone, and phentermine/
topiramate—have been recently added to the pharmacological arsenal for obesity treatment …

Interventions to address cardiovascular risk in obese patients: many hands make light work

V Visco, C Izzo, D Bonadies, F Di Feo… - Journal of …, 2023 - mdpi.com
Obesity is a growing public health epidemic worldwide and is implicated in slowing
improved life expectancy and increasing cardiovascular (CV) risk; indeed, several obesity …

The role of the nucleus accumbens and ventral pallidum in feeding and obesity

S Gendelis, D Inbar, YM Kupchik - Progress in Neuro …, 2021 - Elsevier
Obesity is a growing global epidemic that stems from the increasing availability of highly-
palatable foods and the consequent enhanced calorie consumption. Extensive research has …

The Appetite Suppressant D-norpseudoephedrine (Cathine) Acts via D1/D2-Like Dopamine Receptors in the Nucleus Accumbens Shell

B Kalyanasundar, CI Perez, B Arroyo… - Frontiers in …, 2020 - frontiersin.org
d-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha
edulis “Khat.” NPE has been widely used as an appetite suppressant for the treatment of …

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

UF Shaik Mohamed Sayed, S Moshawih… - Frontiers in …, 2023 - frontiersin.org
Obesity affects more than 10% of the adult population globally. Despite the introduction of
diverse medications aimed at combating fat accumulation and obesity, a significant number …