Second-generation antipsychotics are widely used for the treatment of schizophrenia.
Aripiprazole (ARI) is classified as a third-generation antipsychotic drug with a high affinity for …

Background: The treatment of schizophrenia is challenging due to the wide range of
symptoms (positive, negative, cognitive) associated with the disease. Typical antipsychotics …

Haloperidol, one of the representative typical antipsychotics, is on the market for
schizophrenia but shows severe adverse effects such as extrapyramidal symptoms (EPS) or …

Cognitive impairments characterize individuals with schizophrenia, and are correlated to the
patients' functional outcome. The transcription factor Cyclic AMP-responsive element …

Introduction: Aripiprazole, a commonly prescribed antipsychotic, has been rarely associated
with the onset of hiccups. This study aims to elucidate the prevalence, risk factors, and …

Abstract Knowledge of heterogeneous etiology and pathophysiology of schizophrenia (SZP)
is reasonably inadequate and non-deterministic due to its inherent complexity and …

Schizophrenia is a serious cognitive disorder characterized by disruptions in
neurotransmission, a process requiring the coordination of multiple kinase-mediated …

Aripiprazole is a D2-like receptor (D2R) partial agonist with a favourable clinical profile.
Previous investigations indicated that acute and short-term administration of aripiprazole …

Postmortem studies suggest that schizophrenia is associated with abnormal expression of
specific GABA A receptor (GABA AR) α subunits, including α5GABA A R. Positron emission …

Brexpiprazole (Bre) is a new multi-target antipsychotic drug (APD) approved by the US FDA
in 2015, and shows good therapeutic potential. But it lacks assessments on the metabolic …