Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

For many pathogens the availability of genome sequence, permitting genome-dependent
methods of research, can partially substitute for powerful forward genetic methods (genome …

Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000
deaths per year worldwide. Vaccine development has proved difficult and resistance has …

The growing resistance to current first-line antimalarial drugs represents a major health
challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient …

Several new fluorescence malaria in vitro drug susceptibility microtiter plate assays that
detect the presence of malarial DNA in infected erythrocytes have recently been reported, in …

The quantitative analysis of Plasmodium development in the liver in laboratory animals in
cultured cells is hampered by low parasite infection rates and the complicated methods …

Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria
elimination and threatens to spread to other malaria endemic areas. Understanding …

Human malaria infection begins with a one-time asymptomatic liver stage followed by a
cyclic symptomatic blood stage. All high-throughput malaria drug discovery efforts have …

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …

A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a
polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration …