Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living
organisms and is denoted as a persistent condition of an imbalance between the generation …

Abstract Malondialdehyde (MDA), 4-hydroxy-nonenal (HNE) and the F 2-isoprostane 15 (S)-
8-iso-prostaglandin F 2α (15 (S)-8-iso-PGF 2α) are the best investigated products of lipid …

Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …

Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

The brain is very sensitive to changes in redox status; thus maintaining redox homeostasis
in the brain is critical for the prevention of accumulating oxidative damage. Aging is the …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

Background Extant data from in vivo animal models and postmortem studies indicate that
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

A great variety of compounds are formed during lipid peroxidation of polyunsaturated fatty
acids of membrane phospholipids. Among them, bioactive aldehydes, such as 4 …

There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …