Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …

Malignancies that develop from mucosal epithelium of the upper aerodigestive tract are
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …

DNA methylation is one of epigenetic changes most frequently studied nowadays, together
with its relationship with oral carcinogenesis. A group of enzymes is responsible for …

Simple Summary This comprehensive review focuses on the role of epigenetics in oral
squamous cell carcinoma (OSCC), a prevalent type of oral cancer. The review highlights the …

Oral cavity squamous cell carcinoma (OCSCC) is a heterogeneous and complex disease
that arises due to dysfunction of multiple molecular signaling pathways. Recent advances in …

Abstract Background: O6-methylguanine-DNA methyltransferase (MGMT) is a specific DNA
damage reversal repair protein. The influence of MGMT status on alkylating agent sensitivity …

Simple Summary Clinically, early-stage oral cancers are difficult to distinguish from oral
potentially malignant disorders (OPMDs) because they show a variety of mucosal …

Background and Objectives: MGMT methylation is a well-described biomarker in several
solid tumors and MLH1 seems to occur in the initial stages of oral carcinogenesis. The aims …

Objective Treatment strategies for oral squamous cell carcinoma (OSCC) vary, depending
on the stage of diagnosis. Surgery and radiotherapy are options for localized lesions for …

In the present study, we aimed at determining the potential role of rs12917 polymorphism of
the O-6-methylguanine-DNA methyltransferase (MGMT) gene in the occurrence of cancer …