[HTML][HTML] ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …
Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers
Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs characterized
by a covalently closed-loop structure generated through a special type of alternative splicing …
by a covalently closed-loop structure generated through a special type of alternative splicing …
Trained immunity and reactivity of macrophages and endothelial cells
Innate immune cells can develop exacerbated immunologic response and long-term
inflammatory phenotype following brief exposure to endogenous or exogenous insults …
inflammatory phenotype following brief exposure to endogenous or exogenous insults …
[HTML][HTML] Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages
C Drummer IV, F Saaoud, NC Jhala, R Cueto… - Frontiers in …, 2023 - frontiersin.org
Introduction Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the
population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges …
population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges …
[HTML][HTML] Recent advancements in antifibrotic therapies for regression of liver fibrosis
Cirrhosis is a severe form of liver fibrosis that results in the irreversible replacement of liver
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …
Resistin: Potential biomarker and therapeutic target in atherosclerosis
L Zhou, JY Li, PP He, XH Yu, CK Tang - Clinica chimica acta, 2021 - Elsevier
Resistin, a cysteine-rich secretory protein, has a pleiotropic role in humans. Resistin usually
presents as trimer or hexamer in plasma, and targets specific receptors Toll Like Receptor 4 …
presents as trimer or hexamer in plasma, and targets specific receptors Toll Like Receptor 4 …
[HTML][HTML] microRNAs in human adipose tissue physiology and dysfunction
A Kurylowicz - Cells, 2021 - mdpi.com
In recent years, there has been a large amount of evidence on the role of microRNA
(miRNA) in regulating adipose tissue physiology. Indeed, miRNAs control critical steps in …
(miRNA) in regulating adipose tissue physiology. Indeed, miRNAs control critical steps in …
Astragaloside IV alleviates Schwann cell injury in diabetic peripheral neuropathy by regulating microRNA-155-mediated autophagy
Y Yin, H Qu, Q Yang, Z Fang, R Gao - Phytomedicine, 2021 - Elsevier
Abstract Background MicroRNA-155 (miR-155) is closely associated with diabetic peripheral
neuropathy (DPN). Astragaloside IV (AST) is a significant extract of Astragalus …
neuropathy (DPN). Astragaloside IV (AST) is a significant extract of Astragalus …
[HTML][HTML] Obesity, insulin resistance, and colorectal cancer: could miRNA dysregulation play a role?
F Cirillo, C Catellani, C Sartori, P Lazzeroni… - International journal of …, 2019 - mdpi.com
Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance
is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs …
is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs …