Annexin A1 as a regulator of immune response in cancer

TG Araújo, STS Mota, HSV Ferreira, MA Ribeiro… - Cells, 2021 - mdpi.com
Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

Annexins in translational research: hidden treasures to be found

S Schloer, D Pajonczyk, U Rescher - International journal of molecular …, 2018 - mdpi.com
The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+) and
phospholipid binding protein family which share a high structural homology. In keeping with …

Extracellular vesicles from cancer-associated fibroblasts containing annexin A6 induces FAK-YAP activation by stabilizing β1 integrin, enhancing drug resistance

T Uchihara, K Miyake, A Yonemura, Y Komohara… - Cancer research, 2020 - AACR
Extracellular vesicles (EV) from cancer-associated fibroblasts (CAF) are composed of
diverse payloads. Although CAFs impact the aggressive characteristics of gastric cancer …

Recombinant annexin A6 promotes membrane repair and protects against muscle injury

AR Demonbreun, KS Fallon… - The Journal of …, 2019 - Am Soc Clin Investig
Membrane repair is essential to cell survival. In skeletal muscle, injury often associates with
plasma membrane disruption. Additionally, muscular dystrophy is linked to mutations in …

Annexin animal models—from fundamental principles to translational research

T Grewal, C Rentero, C Enrich, M Wahba… - International Journal of …, 2021 - mdpi.com
Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …

[HTML][HTML] Annexin A1 involved in the regulation of inflammation and cell signaling pathways

PF Han, XD Che, HZ Li, YY Gao, XC Wei… - Chinese Journal of …, 2020 - Elsevier
With the deepening of research, proteomics has developed into a science covering the study
of all the structural and functional characteristics of proteins and the dynamic change rules …

[HTML][HTML] A conserved annexin A6–mediated membrane repair mechanism in muscle, heart, and nerve

AR Demonbreun, E Bogdanovic, LA Vaught… - JCI insight, 2022 - ncbi.nlm.nih.gov
Membrane instability and disruption underlie myriad acute and chronic disorders. Anxa6
encodes the membrane-associated protein annexin A6 and was identified as a genetic …

Proteins in stool as biomarkers for non‐invasive detection of colorectal adenomas with high risk of progression

MA Komor, LJW Bosch, VMH Coupé… - The Journal of …, 2020 - Wiley Online Library
Screening to detect colorectal cancer (CRC) in an early or premalignant state is an effective
method to reduce CRC mortality rates. Current stool‐based screening tests, eg fecal …

SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growth

Z Sheng, X Cao, Y Deng, X Zhao, S Liang - Cell Communication and …, 2023 - Springer
Abstract Background The Annexin A6 (AnxA6) protein is known to inhibit the epidermal
growth factor receptor (EGFR)-extracellular signal regulated kinase (ERK) 1/2 signaling …

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

L Prieto-Fernández, ST Menéndez… - Frontiers in cell and …, 2022 - frontiersin.org
Annexins are an extensive superfamily of structurally related calcium-and phospholipid-
binding proteins, largely conserved and widely distributed among species. Twelve human …