Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

The development of refractory tumor cells limits therapeutic efficacy in cancer by activating
mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival …

Genome-wide characterization of the in vivo cellular response to perturbation is fundamental
to understanding how cells survive stress. Identifying the proteins and pathways perturbed …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Abstract Treatment regimens for acute myeloid leukemia (AML) continue to offer weak
clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a …

On account of incurable castration-resistant prostate cancer (CRPC) inevitably developing
after treating with androgen deprivation therapy, it is an urgent need to find new therapeutic …

Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and
despite treatment advances, patient prognosis remains poor. During routine animal studies …

Autophagy is a conserved homeostatic process active in all human cells and affecting a
spectrum of diseases. Here we use a pharmaceutical screen to discover new mechanisms …

Simple Summary Although non-prescription anthelmintics are often used for cancer
treatment, there is a lack of information regarding their anti-cancer effects in clinical settings …

Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis
and metastasis are among the primary concerns that limit the efficacy of anticancer …