Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion
in the brain and in the periphery. Kynurenines display a wide range of biological actions …

The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over
the years, studies on energy metabolism primarily focused on the neuronal component of …

Background: TREM2 expressed on microglia plays an important role in modulating
inflammation in neurodegenerative diseases. It remains unknown whether TREM2 …

Resveratrol (RESV), a polyphenolic natural compound, has long been acknowledged to
have cardioprotective and antiinflammatory actions. Evidence suggests that RESV has …

Preclinical studies have suggested that chronic inflammation in the brain might be
associated with multiple metabolic disorders, including obesity and diabetes. In particular …

Diabetic encephalopathy is characterized by impaired cognitive functions that involve
neuronal damage triggered by glucose driven oxidative stress. The objective of the present …

By using pseudorabies virus expressing green fluorescence protein, we found that efferent
bone marrow–neural connections trace to sympathetic centers of the central nervous system …

The brain incorporates and coordinates information based on the hormonal environment,
receiving information from peripheral tissues through the circulation. Although it was initially …

This study was conducted to determine the effect of gestational diabetes on the neuronal
density of CA1 and CA3 subfields of the hippocampus in Wistar rat offspring. On day 1 of …