Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic,
cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving …

AKI is a common complication of sepsis and is significantly associated with mortality. Sepsis
accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The …

Background Septic shock is associated with decreased vasopressor responsiveness.
Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) …

Objectives: Propofol-based sedation may increase hemodynamic instability by decreasing
vascular tone and venous return. Incremental exogenous catecholamines doses may be …

There is growing evidence both in the perioperative period and in the field of intensive care
(ICU) on the association between left ventricular diastolic dysfunction (LVDD) and worse …

Agonists of α2‐adrenoceptors are increasingly being used for the provision of comfort,
sedation and the management of delirium in critically ill patients, with and without sepsis. In …

Background The α2 agonists, dexmedetomidine and clonidine, are used as sedative drugs
during critical illness. These drugs may have anti-inflammatory effects, which might be …

Background Global and intra-renal perfusion and oxygenation may be affected by the choice
of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on …

Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney
injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …