Towards interpretable imaging genomics analysis: Methodological developments and applications

X Cen, W Dong, W Lv, Y Zhao, F Dubee, AFA Mentis… - Information …, 2024 - Elsevier
Identifying the relationship between imaging features and genetic variation (a term coined
“imaging genomics”) offers valuable insight into the pathogenesis of cancer, as well as …

The genetic relationships between brain structure and schizophrenia

EM Stauffer, RAI Bethlehem, L Dorfschmidt… - Nature …, 2023 - nature.com
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …

Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain

JW Vogel, AF Alexander-Bloch… - Proceedings of the …, 2024 - National Acad Sciences
Cortical arealization arises during neurodevelopment from the confluence of molecular
gradients representing patterned expression of morphogens and transcription factors …

[HTML][HTML] Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology

SA Bedford, MC Lai, MV Lombardo, B Chakrabarti… - Biological …, 2024 - Elsevier
Background Autism and attention deficit hyperactivity disorder (ADHD) are heterogeneous
neurodevelopmental conditions with complex underlying neurobiology that is still poorly …

Genetic architecture of the structural connectome

M Wainberg, NJ Forde, S Mansour, I Kerrebijn… - Nature …, 2024 - nature.com
Myelinated axons form long-range connections that enable rapid communication between
distant brain regions, but how genetics governs the strength and organization of these …

Human cortex development is shaped by molecular and cellular brain systems

LD Lotter, A Saberi, JY Hansen, B Misic, GJ Barker… - 2024 - pure.mpg.de
Human brain morphology undergoes complex developmental changes with diverse regional
trajectories. Various biological factors influence cortical thickness development, but human …

A Unifying Hypothesis for the Genome Dynamics Proposed to Underlie Neuropsychiatric Phenotypes

GS Gericke - Genes, 2024 - mdpi.com
The sheer number of gene variants and the extent of the observed clinical and molecular
heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified …

Regional patterns of human cortex development correlate with underlying neurobiology

LD Lotter, A Saberi, JY Hansen, B Misic… - Nature …, 2024 - nature.com
Human brain morphology undergoes complex changes over the lifespan. Despite recent
progress in tracking brain development via normative models, current knowledge of …

JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression

J Mbatchou, MS McPeek - The American Journal of Human Genetics, 2024 - cell.com
Joint association analysis of multiple traits with multiple genetic variants can provide insight
into genetic architecture and pleiotropy, improve trait prediction, and increase power for …

[HTML][HTML] Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation

J Shen, Y Zhang, Z Zhu, Y Cheng, B Cai, Y Zhao… - NeuroImage, 2024 - Elsevier
Heritability and genetic covariance/correlation quantify the marginal and shared genetic
effects across traits. They offer insights on the genetic architecture of complex traits and …