The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Ageing is the greatest risk factor for most common chronic human diseases, and it therefore
is a logical target for developing interventions to prevent, mitigate or reverse multiple age …

Globally, the lifespan of populations increases but the healthspan is lagging behind.
Previous research showed that survival into extreme ages (longevity) clusters in families as …

The familial resemblance in length of adult life is very modest. Studies of parent‐offspring
and twins suggest that exceptional health and survival have a stronger genetic component …

It is known that biological relatives of long-lived individuals demonstrate lower mortality and
longer life span compared to relatives of shorter-lived individuals, and at least part of this …

Life-history traits (traits directly related to survival and reproduction) co-evolve and
materialize through physiology and behavior. Accordingly, lifespan can be hypothesized as …

Aim: Longevity accumulating in families has genetic and epigenetic components. To study
early and unbiased epigenetic predictors of longevity prospectively, a birth cohort would be …

Niels van den Berg www. aging-us. com AGING 2020, Vol. 12, No. 22 www. aging-us. com
22354 AGING and socio-behavioral and environmental components (G x E interactions). To …

Background A recent study suggested that the protective effect of familial longevity becomes
negligible for centenarians. However, the authors assessed the dependence on familial …

Abstract Research Question It is unknown whether better long-term somatic maintenance is
directly related to reproductive health facets, and whether there is a shared, and possibly …