Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation,
however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA …

Abnormal function of suborganelles such as mitochondria and endoplasmic reticulum often
leads to abnormal function of cardiomyocytes or vascular endothelial cells and …

Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …

Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are not only
critical for the communication between two organelles but also crucial for cellular processes …

Significance: Mitochondria-Associated Membranes (MAMs) are highly dynamic endoplasmic
reticulum (ER)-mitochondria contact sites that, due to the transfer of lipids and Ca2+ …

Recent research has emphasized the significance of investigating the interplay between
organelles, with endoplasmic reticulum mitochondria contact sites (ERMCSs) being …

Endoplasmic reticulum–mitochondria contact sites (ERMCSs) are dynamic contact regions
with a distance of 10–30 nm between the endoplasmic reticulum and mitochondria …