Biomarkers for early detection of cancer: molecular aspects

PS Tappia, B Ramjiawan - International journal of molecular sciences, 2023 - mdpi.com
According to the World Health Organization, cancer is a leading cause of death worldwide,
representing almost 10 million deaths in 2020. In other words, approximately one death out …

The implication of X-linked genetic polymorphisms in susceptibility and sexual dimorphism of cancer

C Achilla, T Papavramidis, L Angelis… - Anticancer …, 2022 - ar.iiarjournals.org
The X-chromosome is implicated in cancer development through various mechanisms,
including X-inactivation defects, loss of heterozygosity, and germline and somatic alterations …

Machine Learning analysis of high-grade serous ovarian cancer proteomic dataset reveals novel candidate biomarkers

F Farinella, M Merone, L Bacco, A Capirchio… - Scientific Reports, 2022 - nature.com
Ovarian cancer is one of the most common gynecological malignancies, ranking third after
cervical and uterine cancer. High-grade serous ovarian cancer (HGSOC) is one of the most …

Is the fundamental pathology in Duchenne's muscular dystrophy caused by a failure of glycogenolysis–glycolysis in costameres?

V Nesari, S Balakrishnan, U Nongthomba - Journal of genetics, 2023 - Springer
Duchenne muscular dystrophy (DMD) is the most common form of progressive childhood
muscular dystrophy associated with weakness of limbs, loss of ambulation, heart weakness …

Identification of circulating miRNAs differentially expressed in patients with Limb-girdle, Duchenne or facioscapulohumeral muscular dystrophies

JL García-Giménez, ER García-Trevijano… - Orphanet journal of rare …, 2022 - Springer
Background Limb-girdle muscular dystrophy (LGMD) is a rare neuromuscular disease
including a growing and heterogeneous number of subtypes with variable phenotype. Their …

Duchenne muscular dystrophy gene expression is an independent prognostic marker for IDH mutant low-grade glioma

M Naidoo, L Jones, B Conboy, W Hamarneh… - Scientific reports, 2022 - nature.com
Alterations in the expression of the Duchenne muscular dystrophy (DMD) gene have been
associated with the development, progression and survival outcomes of numerous cancers …

[HTML][HTML] Differential expression of DMD transcripts as a novel prognostic biomarker in histologically diverse mesotheliomas

N Alnassar, JMJ Derry, GL Banna… - … Lung Cancer Research, 2024 - ncbi.nlm.nih.gov
Background The identification of prognostic biomarkers is crucial for guiding treatment
strategies in mesothelioma patients. The Duchenne muscular dystrophy (DMD) gene and its …

Comprehensive genomic analysis of puerarin in inhibiting bladder urothelial carcinoma cell proliferation and migration

YY Ma, G Zhang, P Liu, Y Liu, J Ding… - Recent Patents on …, 2024 - ingentaconnect.com
Background: Bladder urothelial carcinoma (BUC) ranks second in the incidence of
urogenital system tumors, and the treatment of BUC needs to be improved. Puerarin, a …

Downregulation of dystrophin expression occurs across diverse tumors, correlates with the age of onset, staging and reduced survival of patients

N Alnassar, M Borczyk, G Tsagkogeorga… - Cancers, 2023 - mdpi.com
Simple Summary Mutations of the DMD gene, encoding dystrophins, cause Duchenne
muscular dystrophy (DMD). We found that while DMD transcription occurs throughout a …

Ablation of the dystrophin Dp71f alternative C-terminal variant increases sarcoma tumour cell aggressiveness

N Alnassar, J Hajto, RMH Rumney… - Human Molecular …, 2024 - academic.oup.com
Alterations in Dp71 expression, the most ubiquitous dystrophin isoform, have been
associated with patient survival across tumours. Intriguingly, in certain malignancies, Dp71 …