Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …

This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

The identification of genes predisposing to familial cancer is an essential step towards
understanding the molecular events underlying tumorigenesis and is critical for the clinical …

We review the role of cadherins and cadherin-related proteins in human cancer. Cellular
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …

As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort
has been concentrated on understanding the processes of metastasis, how a primary …

E-cadherin tumor suppressor genes are particularly active area of research in development
and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are …

Hereditary factors account for a significant proportion of breast cancer risk. Approximately
20% of hereditary breast cancers are attributable to pathogenic variants in the highly …

Invasive lobular carcinoma (ILC) is the second most common type of invasive breast cancer
after invasive ductal carcinoma (IDC). Invasive lobular carcinoma has unique clinical …

Compelling experimental evidence exists for a potent invasion suppressor role of the cell‐
cell adhesion molecule E‐cadherin. In addition, a tumour suppressor effect has been …

Cadherins play an important role in specific cell-cell adhesion events. Their expression
appears to be tightly regulated during development and each tissue or cell type shows a …