Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production,
which is highly associated with normal physiological homeostasis and the pathogenesis of …

Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and
antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell …

The retinal pigment epithelium (RPE) is a highly specialized and polarized epithelial cell
layer that plays an important role in sustaining the structural and functional integrity of …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Age‐related macular degeneration (AMD) is a leading cause of severe visual loss and
irreversible blindness in the elderly population worldwide. Retinal pigment epithelial (RPE) …

Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
elderly population with unclear pathogenic mechanism. Herein, we detect downregulated …

Background Age-related macular degeneration (AMD) leads to gradual central vision loss
and eventual irreversible blindness. Melatonin, an endogenous hormone, exhibits anti …

Diabetic retinopathy (DR) is a major cause of blindness in adult, and the accumulation of
advanced glycation end products (AGEs) is a major pathologic event in DR. Methylglyoxal …

Arterial media calcification is related to mitochondrial dysfunction. Protective mitophagy
delays the progression of vascular calcification. We previously reported that lactate …