This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Recent studies in humans and animal models have highlighted that modulation of stearoyl-
coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly …

Recently, nonalcoholic steatohepatitis (NASH) was found to be correlated with
cardiovascular disease events independently of the metabolic syndrome. The aim of this …

Ketogenic diets have been used as an approach to weight loss on the basis of the
theoretical advantage of a low-carbohydrate, high-fat diet. To evaluate the physiological and …

Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X
receptor, and peroxisome proliferator-activated receptors (PPARs), precisely control energy …

Summary Stearoyl-CoA desaturase-1 (SCD1), a critical regulator of energy metabolism,
catalyzes the synthesis of monounsaturated fats. To understand the tissue-specific role of …

Stearoyl‐CoA desaturase 1 (SCD1) is an essential lipogenic enzyme that has been shown
to play an intrinsic role in the development of obesity and related conditions, such as insulin …

Different lipid fractions in humans have characteristic fatty acid profiles and these are
maintained partly through diet and to a lesser extent through endogenous synthesis. The …

Lipogenic diets that are completely devoid of methionine and choline (MCD) induce hepatic
steatosis. MCD feeding also provokes systemic weight loss, for unclear reasons. In this …

OBJECTIVE—To determine whether 1) hepatic ceramide and diacylglycerol concentrations,
2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic …