Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Yeast cells sense the amount and quality of external nutrients through multiple
interconnected signaling networks, which allow them to adjust their metabolism …

The nuclear envelope is a double membrane that separates the nucleus from the cytoplasm.
The inner nuclear membrane (INM) functions in essential nuclear processes including …

Nitrogen is an essential nutrient for yeast during alcoholic fermentation. Nitrogen is involved
in the biosynthesis of protein, amino acids, nucleotides, and other metabolites, including …

The budding yeast Saccharomyces cerevisiae is a eukaryotic microorganism that is able to
choose between different unicellular and multicellular lifestyles. The potential of individual …

Yeast cells rely on the SPS-sensing pathway to respond to extracellular amino acids. This
nutrient-induced signal transduction pathway regulates gene expression by controlling the …

2-Phenylethanol (2-PE) is an important flavouring ingredient with a persistent rose-like
odour, and it has been widely utilized in food, perfume, beverages, and medicine. Due to the …

Protein homeostasis, or proteostasis, is crucial for the functioning of a cell, as proteins that
are mislocalized, present in excessive amounts, or aberrant due to misfolding or other type …

Four types of antifungal drugs are available that include inhibitors of ergosterol synthesis, of
fungal RNA biosynthesis, and of cell wall biosynthesis as well as physiochemical regulators …

Candida albicans possesses a plasma membrane-localized sensor of extracellular amino
acids. Here, we show that in response to amino acids, this sensor induces the proteolytic …