Recent advances in 3-aminoindazoles as versatile synthons for the synthesis of nitrogen heterocycles

Y Guo, Q Gao - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Nitrogen-based heterocycles are an important class of structural scaffolds distributed in
biologically active natural products, medicinal chemistry, and agrochemicals. Hence, there is …

The Groebke–Blackburn–Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019–2023)

C Martini, MID Mardjan, A Basso - Beilstein Journal of Organic …, 2024 - beilstein-journals.org
Abstract The Groebke–Blackburn–Bienaymé (GBB) three-component reaction, discovered in
1998, is a very efficient strategy to assemble imidazo [1, 2-a]-heterocycles starting from …

Synthesis of Imidazo[1,2-a]pyridine-Fused 1,3-Benzodiazepine Derivatives with Anticancer Activity via a One-Pot Cascade GBB-3CR/Pd(II)-Catalyzed Azide …

CR Zhong, YH Zhang, G Yao, HL Zhu… - The Journal of …, 2023 - ACS Publications
A new one-pot synthesis of imidazo [1, 2-a] pyridine-fused 1, 3-benzodiazepine derivatives
via a sequential GBB-3CR/Pd (II)-catalyzed azide-isocyanide coupling/cyclization process …

Domino Cyclization Reaction of o-Diisocyanoarenes for the Synthesis of Imidazo[1,2-a]pyridinobenzimidazole Backbones

M Rezaei-Gohar, K Amiri, K Aghaie… - Organic …, 2023 - ACS Publications
An efficient procedure to access a variety of connected imidazo [1, 2-a] pyridine and
benzimidazole skeletons through the C–N bond was described as a new type of Buchwald …

Diastereoselective Construction of Spirocyclic Isobenzofurans via a Tandem Michael Addition/5-Exo-dig Cyclization Reaction

S Mehdidoust, S Rajai-Daryasarei… - The Journal of …, 2024 - ACS Publications
A practical approach for rapid and efficient access to spirocyclic isobenzofurans is
described. The reaction proceeds through the cycloaddition of 1, 6-ynenone derivatives and …

Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons

K Aghaie, K Amiri, M Rezaei-Gohar… - Chemical …, 2024 - pubs.rsc.org
We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with
nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic …

Synthesis of Azonia Aromatic Heterocycles Bearing 6–6–6–5–6 Pentacyclic Core via Intramolecular [4+ 2]-Cycloaddition and Oxidative Aromatization Reaction …

MK Saini, K Prajapati, AK Basak - The Journal of Organic …, 2023 - ACS Publications
Cationic aza-heterocycle-fused compounds have gained wide applications in materials
science, biological applications, and synthetic organic chemistry. In this report, synthesis of …

Synthesis of Triazolo[4′,5′:4,5]furo[2,3-c]pyridine via Post Modification of an Unusual Groebke–Blackburn–Bienaymé Multicomponent Reaction

A Batra, M Kaur, D Kaushik, S Kaur, MT Patil… - ACS …, 2024 - ACS Publications
The Groebke–Blackburn–Bienaymé (GBB) reaction is a well-established three-component
reaction for synthesizing imidazofused scaffolds from heterocyclic amidines, aldehydes, and …

New efficient synthesis of polysubstituted benzo [d] pyrido [1′, 2': 1, 2] imidazo [4, 5-f][1, 3] diazepines and pyrido [2′, 1': 2, 3] imidazo [1, 5-c] quinazolin-7-ium salts …

L Zhao, ML Yang, HR Chen, MW Ding - Tetrahedron, 2024 - Elsevier
A new efficient synthesis of polysubstituted benzo [d] pyrido [1′, 2': 1, 2] imidazo [4, 5-f][1, 3]
diazepines and pyrido [2′, 1': 2, 3] imidazo [1, 5-c] quinazolin-7-ium salts via sequential …

Divergent Reaction of Allenoates: Synthesis of Polysubstituted Pyrazoles and N‐Alkylated Hydrazones

S Rajai‐Daryasarei, F Rominger… - Advanced Synthesis …, 2022 - Wiley Online Library
A strategy for the divergent synthesis of polysubstituted pyrazoles and N‐alkylated
hydrazone derivatives through three‐component reaction of aromatic aldehydes, aryl …