The immunobiology and pathogenesis of celiac disease
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …
immunopathogenesis that is particularly well understood. The condition is characterized by …
HLA variation and disease
Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …
HLA molecules have proven to be central to physiology, protective immunity and …
Autoimmunity-associated T cell receptors recognize HLA-B* 27-bound peptides
Human leucocyte antigen B* 27 (HLA-B* 27) is strongly associated with inflammatory
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …
diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that …
T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies
JA Tye-Din, HJ Galipeau, D Agardh - Frontiers in pediatrics, 2018 - frontiersin.org
Our understanding of celiac disease and how it develops has evolved significantly over the
last half century. Although traditionally viewed as a pediatric illness characterized by …
last half century. Although traditionally viewed as a pediatric illness characterized by …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease
Celiac disease (CD) is an autoimmune disease in which intestinal inflammation is induced
by dietary gluten. The means through which gluten-specific CD4+ T cell activation …
by dietary gluten. The means through which gluten-specific CD4+ T cell activation …
A human autoimmune organoid model reveals IL-7 function in coeliac disease
In vitro models of autoimmunity are constrained by an inability to culture affected epithelium
alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is …
alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is …
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
SW Scally, J Petersen, SC Law, NL Dudek… - Journal of Experimental …, 2013 - rupress.org
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-
DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of …
DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of …
T cells in celiac disease
Celiac disease is a human T cell–mediated autoimmune-like disorder caused by exposure
to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T …
to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T …