The potential of in vitro neuronal networks cultured on micro electrode arrays for biomedical research

M Cerina, MC Piastra, M Frega - Progress in Biomedical …, 2023 - iopscience.iop.org
In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Dissociated cortical networks show spontaneously correlated activity patterns during in vitro development

M Chiappalone, M Bove, A Vato, M Tedesco… - Brain research, 2006 - Elsevier
In vitro cultured neuronal networks coupled to microelectrode arrays (MEAs) constitute a
valuable experimental model for studying changes in the neuronal dynamics at different …

PPy/SWCNTs-modified microelectrode Array for learning and memory model construction through electrical stimulation and detection of in vitro hippocampal neuronal …

Y Yang, Y Deng, S Xu, Y Liu, W Liang… - ACS Applied Bio …, 2023 - ACS Publications
The learning and memory functions of the brain remain unclear, which are in urgent need for
the detection of both a single cell signal with high spatiotemporal resolution and network …

Evaluation of the performance of information theory-based methods and cross-correlation to estimate the functional connectivity in cortical networks

M Garofalo, T Nieus, P Massobrio, S Martinoia - PloS one, 2009 - journals.plos.org
Functional connectivity of in vitro neuronal networks was estimated by applying different
statistical algorithms on data collected by Micro-Electrode Arrays (MEAs). First we tested …

Network plasticity in cortical assemblies

M Chiappalone, P Massobrio… - European Journal of …, 2008 - Wiley Online Library
To investigate distributed synaptic plasticity at the cell assembly level, we used dissociated
cortical networks from embryonic rats grown on grids of 60 extracellular substrate …

Connecting neurons to a mobile robot: an in vitro bidirectional neural interface

A Novellino, PD′ Angelo, L Cozzi… - Computational …, 2007 - Wiley Online Library
One of the key properties of intelligent behaviors is the capability to learn and adapt to
changing environmental conditions. These features are the result of the continuous and …

A microelectrode array (MEA) integrated with clustering structures for investigating in vitro neurodynamics in confined interconnected sub-populations of neurons

L Berdondini, M Chiappalone, PD Van Der Wal… - Sensors and Actuators B …, 2006 - Elsevier
Understanding how the information is coded in large neuronal networks is one of the major
challenges for neuroscience. A possible approach to investigate the information processing …

Order-based representation in random networks of cortical neurons

G Shahaf, D Eytan, A Gal, E Kermany… - PLoS computational …, 2008 - journals.plos.org
The wide range of time scales involved in neural excitability and synaptic transmission might
lead to ongoing change in the temporal structure of responses to recurring stimulus …

Film‐based implants for supporting neuron–electrode integrated interfaces for the brain

MD Tang‐Schomer, X Hu… - Advanced functional …, 2014 - Wiley Online Library
Neural engineering provides promise for cell therapy by integrating the host brain with brain–
machine‐interface technologies in order to externally modulate functions. Long‐term …

Conditional firing probabilities in cultured neuronal networks: a stable underlying structure in widely varying spontaneous activity patterns

J le Feber, WLC Rutten, J Stegenga… - Journal of neural …, 2007 - iopscience.iop.org
To properly observe induced connectivity changes after training sessions, one needs a
network model that describes individual relationships in sufficient detail to enable …