The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

Evaluation of the use of therapeutic peptides for cancer treatment

S Marqus, E Pirogova, TJ Piva - Journal of biomedical science, 2017 - Springer
Cancer along with cardiovascular disease are the main causes of death in the industrialised
countries around the World. Conventional cancer treatments are losing their therapeutic …

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

A Varanko, S Saha, A Chilkoti - Advanced drug delivery reviews, 2020 - Elsevier
Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …

Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Fusion proteins for half-life extension of biologics as a strategy to make biobetters

WR Strohl - BioDrugs, 2015 - Springer
The purpose of making a “biobetter” biologic is to improve on the salient characteristics of a
known biologic for which there is, minimally, clinical proof of concept or, maximally …

Nanobody-based products as research and diagnostic tools

T De Meyer, S Muyldermans, A Depicker - Trends in biotechnology, 2014 - cell.com
Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain
antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

[HTML][HTML] Research advances in peptide‒drug conjugates

L Gong, H Zhao, Y Liu, H Wu, C Liu, S Chang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently
coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy …

Expression of single-domain antibody in different systems

Y Liu, H Huang - Applied microbiology and biotechnology, 2018 - Springer
Camelid single-domain antibodies (sdAbs, VHHs, or Nanobodies®) are types of antibody
fragments that are composed of the heavy-chain variable domain only. These VHHs …

Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines

J Despanie, JP Dhandhukia, SF Hamm-Alvarez… - Journal of Controlled …, 2016 - Elsevier
Elastin-like polypeptides (ELPs) constitute a genetically engineered class of 'protein
polymers' derived from human tropoelastin. They exhibit a reversible phase separation …