Background This narrative review aims to broaden our understanding of the epidemiology,
burden and clinical spectrum of cluster headache based on updated findings with a global …

Background/Hypothesis Cluster headache displays uniquely rhythmic patterns in its attack
manifestation. This strong chronobiological influence suggests that part of the …

Background Cluster headache is a less-prevalent primary headache disorder but is
overrepresented with regards to use of health care and social services. More insight into the …

Importance Trigeminal autonomic cephalalgias (TACs) comprise a unique collection of
primary headache disorders characterized by moderate or severe unilateral pain, localized …

Background The role of calcitonin gene-related peptide (CGRP) in the cyclic pattern of
cluster headache is unclear. To acquire biological insight and to comprehend why only …

Objective Headache disorders like migraine show geographic and ethnic differences
between Asian and European/North American countries. In cluster headache, these …

Background Cluster headache exists diagnostically in a chronic and episodic variant
between which patients can convert. We aimed to describe how many patients change …

Background Pharmacological treatment of cluster headache constitutes the core of clinical
management, but evidence is sparse. We aimed to generate insight in the existing treatment …

The cluster headache is a primary headache characterized by attacks of unilateral pain
associated with ipsilateral cranial autonomic features. These attacks recur in clusters during …

Cluster headache is uniquely rhythmic in its occurrence both diurnally and annually. This
has implications for the clinical approach to the patient but also for our understanding of the …