Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

The ability to regenerate missing body parts exists throughout the animal kingdom.
Positional information is crucial for regeneration, but how it is harboured and used by …

Wnts are evolutionarily conserved signaling proteins with essential roles in development
and disease that have often been thought to spread between cells and signal at a distance …

Planarian flatworms maintain their body plan in the face of constant internal turnover and
can regenerate from arbitrary tissue fragments. Both phenomena require self-maintaining …

Planarians have a long history in the fields of developmental and regenerative biology.
These animals have also sparked interest in neuroscience due to their neuroanatomy …

Planarian behavior, physiology, and pattern control offer profound lessons for regenerative
medicine, evolutionary biology, morphogenetic engineering, robotics, and unconventional …