Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Natural killer cells: from innate to adaptive features

AM Mujal, RB Delconte, JC Sun - Annual review of immunology, 2021 - annualreviews.org
Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

[HTML][HTML] Targeting immune dysfunction in aging

S Borgoni, KS Kudryashova, K Burka… - Ageing research …, 2021 - Elsevier
Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …

Human immunology and immunotherapy: main achievements and challenges

J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

The land-scape of immune response to monkeypox virus

H Li, QZ Huang, H Zhang, ZX Liu, XH Chen, LL Ye… - …, 2023 - thelancet.com
Human monkeypox is a viral zoonotic smallpox-like disease caused by the monkeypox virus
(MPXV) and has become the greatest public health threat in the genus Orthopoxvirus after …

[HTML][HTML] Targeting inflammation and immunosenescence to improve vaccine responses in the elderly

B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

Latency reversal plus natural killer cells diminish HIV reservoir in vivo

JT Kim, TH Zhang, C Carmona, B Lee, CS Seet… - Nature …, 2022 - nature.com
HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected
cells. Previous studies have shown that natural killer cells are important to inhibiting HIV …

Ice sheets matter for the global carbon cycle

JL Wadham, JR Hawkings, L Tarasov… - Nature …, 2019 - nature.com
The cycling of carbon on Earth exerts a fundamental influence upon the greenhouse gas
content of the atmosphere, and hence global climate over millennia. Until recently, ice …