The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
Defining memory CD8 T cell
MD Martin, VP Badovinac - Frontiers in immunology, 2018 - frontiersin.org
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …
cells differing in phenotype and function. This review will focus on our current understanding …
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
M Dudek, D Pfister, S Donakonda, P Filpe, A Schneider… - Nature, 2021 - nature.com
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …
Understanding subset diversity in T cell memory
SC Jameson, D Masopust - Immunity, 2018 - cell.com
Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy
Patients with low-immunogenic tumors respond poorly to immune checkpoint blockade (ICB)
targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway …
targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway …
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Our current understanding of immunology was largely defined in laboratory mice, partly
because they are inbred and genetically homogeneous, can be genetically manipulated …
because they are inbred and genetically homogeneous, can be genetically manipulated …
KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity
D Herndler-Brandstetter, H Ishigame, R Shinnakasu… - Immunity, 2018 - cell.com
Protective immunity against pathogens depends on the efficient generation of functionally
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …
[HTML][HTML] The chemokine receptor CX3CR1 defines three antigen-experienced CD8 T cell subsets with distinct roles in immune surveillance and homeostasis
Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give
rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that …
rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that …
[HTML][HTML] Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts
Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
Heterogenous populations of tissue-resident CD8+ T cells are generated in response to infection and malignancy
Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …
surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and …