Recent advances in the synthesis and antioxidant activity of low molecular mass organoselenium molecules

JM Anghinoni, PT Birmann, MJ da Rocha, CS Gomes… - Molecules, 2023 - mdpi.com
Selenium is an essential trace element in living organisms, and is present in selenoenzymes
with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR) …

Cyclic seleninate esters, spirodioxyselenuranes and related compounds: new classes of biological antioxidants that emulate glutathione peroxidase

KN Sands, TA Tuck, TG Back - Chemistry–A European Journal, 2018 - Wiley Online Library
Selenium compounds play an important role in redox homeostasis in living organisms. One
of their major functions is to suppress the harmful effects of hydrogen peroxide …

Benzoimidazolyl Organoseleniums: Antioxidant Activity and Catalysts for Selective Iodination of Arenes and Nitro-Michael Reaction

M Batabyal, D Chaurasia, PR Panda… - The Journal of …, 2024 - ACS Publications
Here, the synthesis and catalytic activities of benzoimidazole-derived organoselenium
compounds have been explored. The synthesized bis (2-benzoimidazolyl) diselenide …

Unexpected formation and potent antioxidant activity of macrocyclic dimers containing disulfide and selenide groups

JDR McMillan, KN Sands, GS Cooney… - Angewandte Chemie …, 2022 - Wiley Online Library
During attempts to prepare spirodithiaselenuranes as GPx mimetics, a series of unexpected
dimeric macrocycles was obtained, each containing two selenide and two disulfide moieties …

Organic selenocompounds: are they the panacea for human illnesses?

PA Nogara, ME Pereira, CS Oliveira, L Orian… - New Journal of …, 2023 - pubs.rsc.org
The selenium element is essential to some life forms and its biological-chemistry function is
mainly performed by the selenol/selenolate moiety (–SeH/–Se–) in a few selenoproteins …

Enhanced glutathione peroxidase activity of water-soluble and polyethylene glycol-supported selenides, related spirodioxyselenuranes, and pincer selenuranes

NMR McNeil, DJ Press, DM Mayder… - The Journal of …, 2016 - ACS Publications
Diaryl selenides containing o-hydroxymethylene substituents function as peroxide-
destroying mimetics of the antioxidant selenoenzyme glutathione peroxidase (GPx), via …

Regulation of tyrosinase enzyme activity by glutathione peroxidase mimics

RK Rai, R Karri, KD Dubey, G Roy - Journal of Agricultural and …, 2022 - ACS Publications
Hydrogen peroxide plays a crucial role in the melanogenesis process by regulating the
activity of the key melanin-forming enzyme tyrosinase, responsible for the browning of fruits …

Janus-faced oxidant and antioxidant profiles of organo diselenides

A Upadhyay, RK Jha, M Batabyal, T Dutta… - Dalton …, 2021 - pubs.rsc.org
To date, organoseleniums are pre-eminent for peroxide decomposition and radical
quenching antioxidant activities. On the contrary, here, a series of Janus-faced …

Glutathione peroxidase-like functions of 1, 2-diselenane-4, 5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates

K Arai, Y Sato, I Nakajima, M Saito, M Sasaki… - Bioorganic & Medicinal …, 2021 - Elsevier
Amphiphilic derivatives of (±)-trans-1, 2-diselenane-4, 5-diol (DST ox) decorated with long
alkyl chains or aromatic substituents via ester linkages were applied as glutathione …

Glutathione Peroxidase-like Antioxidant Activity of 1,3-Benzoselenazoles: Synthesis and In Silico Molecular Docking Studies as Pancreatic Lipase Inhibitors

M Yadav, VP Singh - The Journal of Organic Chemistry, 2023 - ACS Publications
The synthesis of 1, 3-benzoselenazoles was achieved by the reaction of corresponding bis
[3-amino-N-(p-tolyl) benzamide-2-yl] diselenide, bis [3-amino-N-(4-methoxyphenyl) …