Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated
in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer …

Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is linked with
increased reactive oxygen species/reactive nitrogen species (ROS/RNS) and oxidative …

Hypertension is a major cardiovascular risk factor. Of the many processes involved in the
pathophysiology of hypertension, vascular damage due to oxidative stress (excess …

Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …

Skeletal muscle shows high plasticity in response to external demand. Moreover, adult
skeletal muscle is capable of complete regeneration after injury, due to the properties of …

Oxidative stress results from an imbalance of the reactive oxygen species/reactive nitrogen
species (ROS/RNS) production and the oxidants defense system. Extensive research during …

Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and
diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial …

A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …