The importance of nickel enzymes, where nickel serves as an essential cofactor, in Archaea,
bacteria, plants, and primitive eukaryotes, is well documented. 1 Despite the fact that no …

Nickel is an essential nutrient for selected microorganisms where it participates in a variety
of cellular processes. Many microbes are capable of sensing cellular nickel ion …

Background: Urease catalyzes the hydrolysis of urea, the final step of organic nitrogen
mineralization, using a bimetallic nickel centre. The role of the active site metal ions and …

This Handbook on Metalloproteins focuses on the available structural information of proteins
and their metal ion coordination spheres. It centers on the metal ions indispensable for life …

Urease, the first enzyme to be crystallized, contains a dinuclear nickel metallocenter that
catalyzes the decomposition of urea to produce ammonia, a reaction of great agricultural …

Covering: up to the end of 2017 The human body is composed of an equal number of
human and microbial cells. While the microbial community inhabiting the human …

This work provides a comprehensive critical summary of urease spectroscopy,
crystallography, inhibitor binding, and site-directed mutagenesis, with special emphasis …

A joint QM/MM and ab initio study on the decomposition of urea in the gas phase and in
aqueous solution is reported. Numerous possible mechanisms of intramolecular …

Soil urease is highly sensitive to soil heavy metal pollution, and thus its activity can be used
as bio-indicator of soil health. However, little is known about the inhibition mechanisms of …

Nickel enzymes are a relatively new class of metalloenzymes. The seven known nickel
enzymes are urease, hydrogenase, CO-dehydrogenase, methyl-coenzyme M reductase, Ni …