Biomaterials and tissue engineering strategies for posterior lamellar eyelid reconstruction: Replacement or regeneration?

Y Yan, Q Ji, R Fu, C Liu, J Yang, X Yin… - Bioengineering & …, 2023 - Wiley Online Library
Reconstruction of posterior lamellar eyelids remains challenging due to their delicate
structure, highly specialized function, and cosmetic concerns. Current clinically available …

Pre-clinical cell-based therapy for limbal stem cell deficiency

A Sehic, ØA Utheim, K Ommundsen… - Journal of functional …, 2015 - mdpi.com
The cornea is essential for normal vision by maintaining transparency for light transmission.
Limbal stem cells, which reside in the corneal periphery, contribute to the homeostasis of the …

Structural and functional changes in corneal innervation after laser in situ keratomileusis and their relationship with dry eye

C Chao, F Stapleton, X Zhou, S Chen, S Zhou… - Graefe's Archive for …, 2015 - Springer
Purpose The most likely etiology of post-LASIK dry eye is corneal nerve damage; however,
no direct relationship between post-LASIK dry eye symptoms and nerve damage has been …

Electrospun nanofibrous SF/P (LLA-CL) membrane: a potential substratum for endothelial keratoplasty

J Chen, C Yan, M Zhu, Q Yao, C Shao… - International journal …, 2015 - Taylor & Francis
Background Cornea transplant technology has progressed markedly in recent decades,
allowing surgeons to replace diseased corneal endothelium by a thin lamellar structure. A …

Is the conjunctiva a potential target for advanced therapy medicinal products?

Y Diebold, L García-Posadas - Pharmaceutics, 2021 - mdpi.com
The conjunctiva is a complex ocular tissue that provides mechanical, sensory, and immune
protection for the ocular surface. It is affected by many diseases through different …

Toward the practical implementation of eye-related bioavailability prediction models

I Pepić, J Lovrić, B Cetina-Čižmek, S Reichl… - Drug discovery today, 2014 - Elsevier
Highlights•Cell-based primary permeability screening.•Tissue-/tissue equivalent-based
secondary permeability screening.•Eye-related bioavailability/bioequivalence.•Efficient …

A novel application of electrospun silk fibroin/poly (l-lactic acid-co-ε-caprolactone) scaffolds for conjunctiva reconstruction

Q Yao, Y Hu, F Yu, W Zhang, Y Fu - RSC advances, 2018 - pubs.rsc.org
Electrospun hybrid nanofibers prepared using combinations of natural and synthetic
polymers have been widely investigated in tissue engineering. In this study, silk fibroin (SF) …

Concise review: comparison of culture membranes used for tissue engineered conjunctival epithelial equivalents

JR Eidet, DA Dartt, TP Utheim - Journal of functional biomaterials, 2015 - mdpi.com
The conjunctival epithelium plays an important role in ensuring the optical clarity of the
cornea by providing lubrication to maintain a smooth, refractive surface, by producing …

[PDF][PDF] Conjunctiva reconstruction by induced differentiation of human amniotic epithelial cells

SP Yang, XZ Yang, GP Cao - Genet Mol Res, 2015 - geneticsmr.com
In this study, we aimed to investigate the feasibility of directed differentiation of human
amniotic epithelial cells into conjunctival epithelium under specific conditions as well as of …

Critical functionality effects from storage temperature on human induced pluripotent stem cell-derived retinal pigment epithelium cell suspensions

S Kitahata, Y Tanaka, K Hori, C Kime, S Sugita… - Scientific Reports, 2019 - nature.com
Human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (hiPSC-
RPE) cells suspension have the potential for regenerative treatment. However, practical …