Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Lipid droplets (LDs) are complex and metabolically active organelles. They are composed of
a neutral lipid core surrounded by a monolayer of phospholipids and proteins. LD …

Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Components of the proteostasis network malfunction in aging, and reduced protein quality
control in neurons has been proposed to promote neurodegeneration. Here, we investigate …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …