Bottom-up mass spectrometry–based proteomics relies on protein digestion and peptide
purification. The application of such methods to broadly available clinical samples such as …

Breast cancer has become the highest incidence of cancer in women. It was extensively and
deeply studied by biologists and medical workers worldwide. However, the meaningful …

The expression and function of the receptor are controlled by epigenetic changes, such as
DNA methylation, histone modification, and noncoding RNAs. These modifications play a …

Purpose The majority of breast cancers are estrogen receptor (ERα) positive making
endocrine therapy a mainstay for these patients. Unfortunately, resistance to endocrine …

Endometrial cancer (EC) is the fourth most common cancer in women. Advanced-stage EC
has limited treatment options with a poor prognosis. There is an unmet need for the …

Most patients with estrogen receptor alpha–positive (ER+) breast cancers initially respond to
treatment but eventually develop therapy resistance with disease progression …

Aberrant activities of various cell cycle and DNA repair proteins promote cancer growth and
progression and render them resistant to therapies. Here, we demonstrate that the anti …

Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70–80% of BC
diagnoses are positive for estrogen receptor (ER) alpha (ERα). The steroid hormone …

Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer. Oncogenic PELP1 is frequently overexpressed in TNBC, and it has been …

Simple Summary The proto-oncogene PELP1 is commonly overexpressed in many cancers
including triple negative breast cancer (TNBC). In this study, we utilized global proteomic …