The biphasic function of microglia in ischemic stroke

Y Ma, J Wang, Y Wang, GY Yang - Progress in neurobiology, 2017 - Elsevier
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Microglia and monocytes/macrophages polarization reveal novel therapeutic mechanism against stroke

M Kanazawa, I Ninomiya, M Hatakeyama… - International journal of …, 2017 - mdpi.com
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types,
ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival …

Immune interventions in stroke

Y Fu, Q Liu, J Anrather, FD Shi - Nature Reviews Neurology, 2015 - nature.com
Approaches for the effective management of acute stroke are sparse, and many measures
for brain protection fail. However, our ability to modulate the immune system and modify the …

Models and mechanisms of vascular dementia

P Venkat, M Chopp, J Chen - Experimental neurology, 2015 - Elsevier
Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease
(AD) plaguing the elderly population. VaD is a progressive disease caused by reduced …

[HTML][HTML] Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

C Stonesifer, S Corey, S Ghanekar, Z Diamandis… - Progress in …, 2017 - Elsevier
Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …

Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling

X Lian, X Bao, A Al-Ahmad, J Liu, Y Wu, W Dong… - Stem cell reports, 2014 - cell.com
Human pluripotent stem cell (hPSC)-derived endothelial cells and their progenitors may
provide the means for vascularization of tissue-engineered constructs and can serve as …

Inflammatory disequilibrium in stroke

D Petrovic-Djergovic, SN Goonewardena… - Circulation …, 2016 - Am Heart Assoc
Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

White matter injury in ischemic stroke

Y Wang, G Liu, D Hong, F Chen, X Ji, G Cao - Progress in neurobiology, 2016 - Elsevier
Stroke is one of the major causes of disability and mortality worldwide. It is well known that
ischemic stroke can cause gray matter injury. However, stroke also elicits profound white …

[HTML][HTML] Stem and progenitor cell-based therapy of the central nervous system: hopes, hype, and wishful thinking

SA Goldman - Cell stem cell, 2016 - cell.com
A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

Enhancing brain plasticity to promote stroke recovery

F Su, W Xu - Frontiers in neurology, 2020 - frontiersin.org
Stroke disturbs both the structural and functional integrity of the brain. The understanding of
stroke pathophysiology has improved greatly in the past several decades. However …