Naturally occurring sulfonium-ion glucosidase inhibitors and their derivatives: a promising class of potential antidiabetic agents
S Mohan, R Eskandari, BM Pinto - Accounts of chemical research, 2014 - ACS Publications
In humans, four different enzymes mediate the digestion of ingested carbohydrates. First
salivary and pancreatic α-amylases, the two endoacting retaining glucosidases, break down …
salivary and pancreatic α-amylases, the two endoacting retaining glucosidases, break down …
α-1-C-Butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a Second-Generation Iminosugar-Based Oral α-Glucosidase Inhibitor for Improving Postprandial Hyperglycemia
A Kato, E Hayashi, S Miyauchi, I Adachi… - Journal of medicinal …, 2012 - ACS Publications
We report on the synthesis and the biological evaluation of a series of α-1-C-alkylated 1, 4-
dideoxy-1, 4-imino-l-arabinitol (LAB) derivatives. The asymmetric synthesis of the derivatives …
dideoxy-1, 4-imino-l-arabinitol (LAB) derivatives. The asymmetric synthesis of the derivatives …
Back to (non-) Basics: an update on neutral and charge-balanced glycosidase inhibitors
MI Simone, LJ Mares, CA Eveleens… - Mini Reviews in …, 2018 - ingentaconnect.com
Glycosidases have important anti-cancer, anti-viral and anti-diabetic properties. This review
covers the literature in the past 15 years since our initial review in this journal on “neutral” …
covers the literature in the past 15 years since our initial review in this journal on “neutral” …
Theoretical Studies for the Discovery of Potential Sucrase-Isomaltase Inhibitors from Maize Silk Phytochemicals: An Approach to Treatment of Type 2 Diabetes
LL Landeros-Martínez, MI Campos-Almazán… - Molecules, 2023 - mdpi.com
A theoretical analysis of the potential inhibition of human sucrase-isomaltase (SI) by
flavonoids was carried out with the aim of identifying potential candidates for an alternative …
flavonoids was carried out with the aim of identifying potential candidates for an alternative …
Network pharmacology combined with metabolomics to study the mechanism of Shenyan Kangfu tablets in the treatment of diabetic nephropathy
Abstract Ethnopharmacological relevance Shenyan Kangfu Tablets (SYKFT) is a traditional
prescription evolved from Shenqi Pills. It has been included in the Synopsis of the Golden …
prescription evolved from Shenqi Pills. It has been included in the Synopsis of the Golden …
Aspects of extraction and biological evaluation of naturally occurring sugar-mimicking sulfonium-ion and their synthetic analogues as potent α-glucosidase inhibitors …
Human maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) are membrane bound
small intestinal α-glucosidase enzymes which are responsible for the hydrolysis of terminal …
small intestinal α-glucosidase enzymes which are responsible for the hydrolysis of terminal …
Modeling of cooked starch digestion process using recombinant human pancreatic α-amylase and maltase-glucoamylase for in vitro evaluation of α-glucosidase …
X Cao, C Zhang, Y Dong, P Geng, F Bai, G Bai - Carbohydrate research, 2015 - Elsevier
In human, digestion of cooked starch mainly involves breaking down of α-amylase to α-limit
dextrins and small linear malto-oligosaccharides, which are in turn hydrolyzed to glucose by …
dextrins and small linear malto-oligosaccharides, which are in turn hydrolyzed to glucose by …
تقدير فعالية إنزيم الفا-كلوكوسيديز مع بعض مضادات الأكسدة لدى مرضى السكر النوع الثاني
OM Abd Al-Hussein, IF Waheed… - Samarra Journal of Pure …, 2024 - sjpas.com
The study included estimating the activity of alpha-glucosidase enzyme with some
biochemical variables in the serum of type 2 diabetics. The study included 50 samples of …
biochemical variables in the serum of type 2 diabetics. The study included 50 samples of …
Glycosidase inhibitors and methods of synthesizing same
BM Pinto, BD Johnston, A Ghavami… - US Patent …, 2013 - Google Patents
2006-06-30 Assigned to SIMON FRASER UNIVERSITY reassignment SIMON FRASER
UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
UNIVERSITY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
50 years of progress since congenital sucrase-isomaltase deficiency recognition
BL Nichols Jr, S Auricchio - Journal of pediatric gastroenterology …, 2012 - journals.lww.com
Fifty-three years ago, Holzel discovered that the chronic diarrhea of 2 malnourished infants
was caused by lactase deficiency (1). The next year, Weijers reported that an identical …
was caused by lactase deficiency (1). The next year, Weijers reported that an identical …