Natural product hybrids as new leads for drug discovery

LF Tietze, HP Bell… - Angewandte Chemie …, 2003 - Wiley Online Library
Natural products play an important role in the development of drugs, especially for the
treatment of infections and cancer, as well as immunosuppressive compounds. However …

Glycals in organic synthesis: the evolution of comprehensive strategies for the assembly of oligosaccharides and glycoconjugates of biological consequence

SJ Danishefsky, MT Bilodeau - … Chemie International Edition in …, 1996 - Wiley Online Library
This review provides a personal account of the explorations of a research group in
oligosaccharide and glycoconjugate construction. The journey began twenty years ago with …

[图书][B] Anticancer agents from natural products

GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Adventures in carbohydrate chemistry: new synthetic technologies, chemical synthesis, molecular design, and chemical biology

KC Nicolaou, HJ Mitchell - Angewandte Chemie International …, 2001 - Wiley Online Library
The field of carbohydrate chemistry has occupied the minds and hearts of many scientists for
over a hundred years and, as we enter the twenty‐first century, it continues to be both …

Chemistry and biology of natural and designed enediynes.

KC Nicolaou, AL Smith, EW Yue - Proceedings of the …, 1993 - National Acad Sciences
Ever since the initial reports of the enediyne anticancer antibiotics in the late 1980s,
researchers from a number of disciplines have been devoting increasing attention to their …

Iodine(V) Reagents in Organic Synthesis. Part 3. New Routes to Heterocyclic Compounds via o-Iodoxybenzoic Acid-Mediated Cyclizations:  Generality, Scope, and …

KC Nicolaou, PS Baran, YL Zhong… - Journal of the …, 2002 - ACS Publications
The discovery and development of the o-iodoxybenzoic acid (IBX) reaction with certain
unsaturated N-aryl amides (anilides) to form heterocycles are described. The application of …

Probing the biology of natural products: molecular editing by diverted total synthesis

AM Szpilman, EM Carreira - Angewandte Chemie International …, 2010 - Wiley Online Library
The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …

Calicheamicins: discovery, structure, chemistry, and interaction with DNA

MD Lee, GA Ellestad, DB Borders - Accounts of Chemical …, 1991 - ACS Publications
Calicheamicins: discovery, structure, chemistry, and interaction with DNA Page 1 Acc. Chem.
Res. 24, 235-243 235 bration under basic conditions. Conversion into the thiopyranone 122 …

Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaccharides

A Kirschning, AFW Bechthold, J Rohr - Bioorganic Chemistry Deoxysugars …, 1997 - Springer
Deoxysugars and the oligosaccharides derived from them belong to one of the most
important, but often most neglected, group of biological compounds. As a result of important …

Chemie und Biologie von Endiin‐Cytostatica/Antibiotica

KC Nicolaou, WM Dai - Angewandte Chemie, 1991 - Wiley Online Library
Neue biologisch aktive Substanzen aus natürlichen Quellen sind für Naturwissenschaftler
und Mediziner oft aufregend, stimulierend sowie Herausforderung und Chance zugleich …