Novel applications of micro total analysis systems (μTAS) are addressing fundamental
biological questions, creating new biomedical reagents, and developing innovative cell and …

In comparison to traditional in vitro cell culture in Petri dishes or well plates, cell culture in
microfluidic‐based devices enables better control over chemical and physical environments …

The generation of functional microvascular networks is critical for the development of
advanced in vitro models to replicate pathophysiological conditions. Mural cells provide …

Engineering 3D perfusable vascular networks in vitro and reproducing the physiological
environment of blood vessels is very challenging for tissue engineering and investigation of …

Abstract Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for
the development of engineered cardiac tissue, facilitating high-throughput testing in drug …

Throughout history, capillary systems have aided the establishment of the fundamental laws
of blood flow and its non-Newtonian properties. The advent of microfluidics technology in the …

We describe a piezoelectric pumping system for studying the mechanobiology of human
aortic endothelial cells (HAECs) under pulsatile flow in microfluidic structures. The system …

Ischemia is a severe condition in which blood supply, including oxygen (O), to organs and
tissues is interrupted and reduced. This is usually due to a clog or blockage in the arteries …

The human circulatory system is a marvelous fluidic system, which is very sensitive to
biophysical and biochemical cues. The current animal and cell culture models do not …

We present an extracellular matrix (ECM)-based stretchable microfluidic system for culturing
in vitro three-dimensional (3D) vascular tissues, which mimics in vivo blood vessels. Human …