[HTML][HTML] An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

S Bastani, V Vahedian, M Rashidi, A Mir… - Biomedicine & …, 2022 - Elsevier
Crocin, an active ingredient derived from saffron, is one of the herbal components that has
recently been considered by researchers. Crocin has been shown to have many anti …

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

F Anaeigoudari, A Anaeigoudari… - Physiological …, 2023 - Wiley Online Library
Application of herbal medicines in the treatment of diseases is in the center of attention of
medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the …

[HTML][HTML] Anti-breast cancer-induced cardiomyopathy: mechanisms and future directions

C Liu, H Chen, S Guo, Q Liu, Z Chen, H Huang… - Biomedicine & …, 2023 - Elsevier
With the progression of tumor treatment, the 5-year survival rate of breast cancer is close to
90%. Cardiovascular toxicity caused by chemotherapy has become a vital factor affecting …

Cardioprotective effects of alpha‐mangostin on doxorubicin‐induced cardiotoxicity in rats

F Eisvand, M Imenshahidi… - Phytotherapy …, 2022 - Wiley Online Library
The main adverse effect of doxorubicin is cardiotoxicity. Oxidative stress and apoptosis
induction have been suggested as mechanisms involved in its cardiotoxicity. In this study …

Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety

A Elfadadny, RF Ragab, R Hamada… - Toxicology and Applied …, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

Metformin and dapagliflozin attenuate doxorubicin-induced acute cardiotoxicity in wistar rats: an Electrocardiographic, Biochemical, and Histopathological Approach

SM Satyam, LK Bairy, P Shetty, P Sainath… - Cardiovascular …, 2023 - Springer
Doxorubicin is a widely used anticancer drug whose efficacy is limited due to its
cardiotoxicity. There is no ideal cardioprotection available against doxorubicin-induced …

Modulating effects of crocin on lipids and lipoproteins: Mechanisms and potential benefits

H Yaribeygi, M Maleki, F Rashid-Farrokhi… - Heliyon, 2024 - cell.com
Dyslipidemia poses a significant risk to cardiovascular health in both diabetic and non-
diabetic individuals. Therefore, it is crucial to normalize lipid homeostasis in order to prevent …

PEG-conjugated bovine haemoglobin enhances efficiency of chemotherapeutic agent doxorubicin with alleviating DOX-induced splenocardiac toxicity in the breast …

B Li, J Zhang, N Ma, W Li, G You, G Chen… - Artificial Cells …, 2023 - Taylor & Francis
Doxorubicin (DOX) is an effective chemotherapeutic agent widely used for cancer treatment.
However, hypoxia in tumour tissue and obvious adverse effects particularly cardiotoxicity …

Effect of Theobroma cacao L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma

PP Patil, P Khanal, VS Patil, R Charla, DR Harish… - Antioxidants, 2022 - mdpi.com
Background and objective: Doxorubicin is a widely used chemotherapeutic agent that
causes oxidative stress leading to cardiotoxicity, hepatotoxicity, and nephrotoxicity. In …

Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury

Z Huang, J Wang, C Li, W Zheng, J He, Z Wu… - Frontiers in …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a devastating central nervous system disease, caused by physical
traumas. With the characteristic of high disability rate, catastrophic dysfunction, and …