Yellow fever, a mosquito-borne viral hemorrhagic fever, is one of the most lethal diseases of
humankind. The etiologic agent is the prototype member of the genus Flavivirus, family …

Yellow fever (YF) virus still represents a major threat in low resource countries in both South
America and Africa despite the presence of an effective vaccine. YF outbreaks are not only …

Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré
syndrome. The ZIKV envelope (E) protein is responsible for viral entry and represents a …

Flaviviruses encode one, two, or no N-linked glycosylation sites on their envelope proteins.
Glycosylation can impact virus interactions with cell surface attachment factors and also may …

Propagation of the flavivirus tick-borne encephalitis virus in BHK-21 cells selected for
mutations within the large surface glycoprotein E that increased the net positive charge of …

E. Heart F. Blood Vessels and Endothelium VI. Pathogenesis and Pathophysiology in the
Intact Host A. Experimental Animal Models B. Spread of Virus within the Host C. Fever and …

Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally
circulate between arthropod vectors and susceptible vertebrate hosts, producing significant …

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Yellow fever (YF) 17D vaccine virus, having a 60-year history of safe and effective use, is an
ideal vector to deliver heterologous genes from other medically important flaviviruses. A …

Yellow fever 17D virus, a safe and effective live, attenuated vaccine, was used as a vector
for genes encoding the protective antigenic determinants of a heterologous member of the …