Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue …
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
RB Haga, AJ Ridley - Small GTPases, 2016 - Taylor & Francis
Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
S Kumagai, Y Togashi, C Sakai, A Kawazoe… - Immunity, 2020 - cell.com
Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we …
K Wang, ST Yuen, J Xu, SP Lee, HHN Yan, ST Shi… - Nature …, 2014 - nature.com
Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …
S Chiba, M Sakata-Yanagimoto - Leukemia, 2020 - nature.com
It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was characterized in the early 1970's. Our understanding of the disease has dramatically …
Whole-genome and centrosome duplication as a consequence of cytokinesis failure can drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …
L Falchi, H Ma, S Klein, JK Lue… - Blood, The Journal …, 2021 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) are uniquely vulnerable to epigenetic modifiers. We demonstrated in vitro synergism between histone deacetylase inhibitors and DNA …