Rho GTPase signaling in cancer progression and dissemination
E Crosas-Molist, R Samain… - Physiological …, 2022 - journals.physiology.org
Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …
The emerging roles of YAP and TAZ in cancer
T Moroishi, CG Hansen, KL Guan - Nature Reviews Cancer, 2015 - nature.com
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ)
are the major downstream effectors of the Hippo pathway, which regulates tissue …
are the major downstream effectors of the Hippo pathway, which regulates tissue …
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
Rho GTPases: Regulation and roles in cancer cell biology
RB Haga, AJ Ridley - Small GTPases, 2016 - Taylor & Francis
Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …
An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T cells
S Kumagai, Y Togashi, C Sakai, A Kawazoe… - Immunity, 2020 - cell.com
Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune
checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we …
checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we …
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
K Wang, ST Yuen, J Xu, SP Lee, HHN Yan, ST Shi… - Nature …, 2014 - nature.com
Gastric cancer is a heterogeneous disease with diverse molecular and histological
subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …
subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with …
Advances in understanding of angioimmunoblastic T-cell lymphoma
S Chiba, M Sakata-Yanagimoto - Leukemia, 2020 - nature.com
It has been nearly half a century since angioimmunoblastic T-cell lymphoma (AITL) was
characterized in the early 1970's. Our understanding of the disease has dramatically …
characterized in the early 1970's. Our understanding of the disease has dramatically …
Cytokinesis defects and cancer
SMA Lens, RH Medema - Nature Reviews Cancer, 2019 - nature.com
Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …
Combined oral 5-azacytidine and romidepsin are highly effective in patients with PTCL: a multicenter phase 2 study
L Falchi, H Ma, S Klein, JK Lue… - Blood, The Journal …, 2021 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) are uniquely vulnerable to epigenetic modifiers. We
demonstrated in vitro synergism between histone deacetylase inhibitors and DNA …
demonstrated in vitro synergism between histone deacetylase inhibitors and DNA …