The proper construction of neural circuits requires the generation of diverse cell types, their
distribution to defined regions, and their specific and appropriate wiring. A major objective in …

Despite decades of research on the neurobiology of major depressive disorder (MDD), the
mechanisms underlying its expression remain unknown. The medial prefrontal cortex …

The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

Optogenetics is a technique for controlling subpopulations of neurons in the intact brain
using light. This technique has the potential to enhance basic systems neuroscience …

To understand how brain states and behaviors are generated by neural circuits, it would be
useful to be able to perturb precisely the activity of specific cell types and pathways in the …

The cerebral cortex, occupying over 70 percent of our brain mass, is key to any
understanding of the workings--and disorders--of the human brain. offering a …

To facilitate the study of the CaMKIIα function in vivo, a CaMKIIα-GFP transgenic mouse line
was generated. Here, our goal is to provide the first neuroanatomical characterization of …

Background: The cortical subplate is a transitory structure involved in the formation of
connections in developing cerebral cortex. Interstitial neurons, normally present in …

Stressful experiences in early life are known risk factors for anxiety and depressive illnesses,
and they inhibit hippocampal neurogenesis and the expression of GABAA receptors in …

Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …