Peripheral nerve regeneration: experimental strategies and future perspectives

A Faroni, SA Mobasseri, PJ Kingham… - Advanced drug delivery …, 2015 - Elsevier
Peripheral nerve injuries represent a substantial clinical problem with insufficient or
unsatisfactory treatment options. This review summarises all the events occurring after nerve …

Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli

MD Sarker, S Naghieh, AD McInnes, DJ Schreyer… - Progress in …, 2018 - Elsevier
Injuries to the peripheral nervous system (PNS) cause neuropathies that lead to weakness
and paralysis, poor or absent sensation, unpleasant and painful neuropathies, and impaired …

Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration

X Gu, F Ding, Y Yang, J Liu - Progress in neurobiology, 2011 - Elsevier
Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

Stem cell transplantation for peripheral nerve regeneration: current options and opportunities

L Jiang, S Jones, X Jia - International journal of molecular sciences, 2017 - mdpi.com
Peripheral nerve regeneration is a complicated process highlighted by Wallerian
degeneration, axonal sprouting, and remyelination. Schwann cells play an integral role in …

Peripheral nerve injury and myelination: Potential therapeutic strategies

M Modrak, MAH Talukder… - Journal of …, 2020 - Wiley Online Library
Traumatic peripheral nerve injury represents a major clinical and public health problem that
often leads to significant functional impairment and permanent disability. Despite modern …

Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges

BJ Pfister, T Gordon, JR Loverde… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Damage to the peripheral nervous system is surprisingly common and occurs primarily from
trauma or a complication of surgery. Although recovery of nerve function occurs in many mild …

Current applications and future perspectives of artificial nerve conduits

X Jiang, SH Lim, HQ Mao, SY Chew - Experimental neurology, 2010 - Elsevier
Artificial nerve guide conduits have the advantage over autografts in terms of their
availability and ease of fabrication. However, clinical outcomes associated with the use of …

Application of stem cells in peripheral nerve regeneration

S Yi, Y Zhang, X Gu, L Huang, K Zhang, T Qian… - Burns & …, 2020 - academic.oup.com
Traumatic peripheral nerve injury is a worldwide clinical issue with high morbidity. The
severity of peripheral nerve injury can be classified as neurapraxia, axonotmesis or …

Electrospun nanofibers for neural tissue engineering

J Xie, MR MacEwan, AG Schwartz, Y Xia - Nanoscale, 2010 - pubs.rsc.org
Biodegradable nanofibers produced by electrospinning represent a new class of promising
scaffolds to support nerve regeneration. We begin with a brief discussion on the …

The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages

J Xie, SM Willerth, X Li, MR Macewan, A Rader… - Biomaterials, 2009 - Elsevier
Due to advances in stem cell biology, embryonic stem (ES) cells can be induced to
differentiate into a particular mature cell lineage when cultured as embryoid bodies …