Kinesin-1 is a typical motile molecular motor and the founding member of the kinesin family.
The most significant feature in the unidirectional motion of kinesin-1 is its processivity. To …

Microtubules (MTs) and their associated proteins play essential roles in maintaining cell
structure, organelle transport, cell motility, and cell division. Two motors, kinesin and …

Cryogenic electron microscopy (cryo-EM) is a powerful technique for determining structures
of multiple conformational or compositional states of macromolecular assemblies involved in …

Viruses with large, double-stranded DNA genomes captured the majority of their genes from
their hosts at different stages of evolution. The origins of many virus genes are readily …

Ciliary beat and intraflagellar transport depend on dynein and kinesin motors. The kinesin-9
family members Kif6 and Kif9 are implicated in motile cilia motilities across protists and …

KIF26B is a member of the kinesin superfamily with evolutionarily conserved functions in
controlling aspects of embryogenesis, including the development of the nervous system …

Background Kinesin motor proteins transport intracellular cargo, including mRNA, proteins,
and organelles. Pathogenic variants in kinesin-related genes have been implicated in …

Kif5A is a neuronally-enriched isoform of the Kinesin-1 family of cellular transport motors. 23
separate mutations in the motor domain of Kif5A have been identified in patients with the …

KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The
mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling …

Background Kinesin motors hydrolyze ATP to produce force and move along microtubules,
converting chemical energy into work by a mechanism that is only poorly understood. Key …